Have your child lie on his back and shut his eyes as tight as he can. Place one to two drops in the inner corner of each eye. Tell him to relax his eyes. The liquid will seep into the eye without tears or fuss! Wipe off the excess with a clean cloth or tissue.I've used this with Jane, and she still fights the drops, but it's easier to do (takes fewer hands to hold flailing limbs, pry open eye lids and squeeze the drops in). Thought it was a good one.
There's also this funny post I found on Today's Parent (but it has an ad wall before it will show you the post, just FYI).